Addex Reports 2017 Full Year Results and Provides Corporate Update

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Robust cash position of CHF45 million following capital raise in Q1 2018Major global licensing agreement with Indivior in addictionGeneva, Switzerland, 30 April 2018 – Addex Therapeutics (SIX: ADXN), a leading company pioneering allosteric modulation-based drug discovery and development, today reported its full-year results for the year ended 31 December 2017 and provided a corporate update.“2017 saw us making significant strides towards rebuilding value for shareholders in Addex. Our concerted efforts in business development and investor relations were rewarded with an important partnership with Indivior PLC, the world's leading developer of addiction treatments, and a transformational financing, both announced during the first quarter 2018,” said Tim Dyer, CEO of Addex. “These significant achievements will allow us to deliver on multiple key product development milestones in 2018, most importantly the start of registrational studies for our lead allosteric modulator, dipraglurant, in levodopa induced dyskinesia associated with Parkinson's disease.”2017 Operating HighlightsContinued preparing dipraglurant for the start of US registration studiesADX71441 programAwarded $5.3 million grant from US National Institute on Drug Abuse to support human studies in the treatment of cocaine use disorderDemonstrated statistically significant effect in preclinical model of osteoarthritic painPreclinical data published on effect in alcohol use disorderAwarded $835,000 grant from The Michael J Fox Foundation for Parkinsons Research to advance TRKB PAMs for the treatment of Parkinson's diseaseKey 2017 Financial DataFinancial Summary
Income in 2017 was CHF0.5 million compared to CHF0.4 million in 2016, and comprised primarily of grants from The Michel J. Fox Foundation for Parkinson's Research to cover certain clinical activities related to dipraglurant development in Parkinson's disease levodopa-induced dyskinesia and discovery activities related to our TrkB PAM program.
On 2 January 2018, the group signed a licencing and collaboration agreement with Indivior PLC for the global development and commercialization of ADX71441 for the treatment of addiction. An upfront payment of USD5.0 million has been received in January 2018.At 31 March 2018, Addex had cash and cash equivalents of approximately CHF45 million.Conference Call Details
A conference call will be held today Monday, 30 April 2018 at 3:00 p.m. CET / 10:00 a.m. EDT to review the financial results. Tim Dyer, Chief Executive Officer, Roger Mills, Chief Medical officer and Robert Lütjens, Head of Discovery will deliver a brief presentation followed by a Q&A session.
Joining the Conference Call:In the 10 minutes prior to the call start time, call the appropriate participant dial-in number.     Dial-In Numbers :Switzerland                 +41 44 580 65 22UK                               +44 20 30 09 24 70US                               +1 87 74 23 08 30Other countriesProvide the operator with the conference ID: 64132152#About Addex Therapeutics
Addex Therapeutics (www.addextherapeutics.com) is a biopharmaceutical company focused on the development of novel, orally available, small molecule allosteric modulators for neurological disorders. Allosteric modulators are an emerging class of small molecule drugs which have the potential to be more specific and confer significant therapeutic advantages over conventional “orthosteric” small molecule or biological drugs. Addex's allosteric modulator drug discovery platform targets receptors and other proteins that are recognized as essential for therapeutic intervention – the Addex pipeline was generated from this pioneering allosteric modulator drug discovery platform. Addex's lead drug candidate, dipraglurant (mGluR5 negative allosteric modulator or NAM) has successfully completed a Phase 2a POC in Parkinson's disease levodopa-induced dyskinesia (PD-LID), and is being prepared to enter registration trials for PD-LID. In parallel, dipraglurant's therapeutic use in dystonia is being investigated. Addex's second clinical program, ADX71149 (mGluR2 positive allosteric modulator or PAM) is being developed in collaboration with Janssen Pharmaceuticals, Inc for epilepsy. In addition, ADX71441 (GABAB receptor PAM) program was awarded a $5.3 million grant by the US National Institute on Drug Abuse (NIDA, a division of National Institutes of Health, NIH) to support human studies in cocaine addiction and has been licensed to Indivior PLC. Discovery programs include GABAB PAM for CMT1A neuropathy, mGluR4PAM, mGluR7NAM, TrkBPAM and mGluR3NAM & PAM.
Press Contacts:Disclaimer / Forward-looking statements: This communication does not constitute an offer or invitation to subscribe for or purchase any securities of Addex Therapeutics Ltd. This publication may contain certain forward-looking statements concerning the Company and its business. Such statements involve certain risks, uncertainties and other factors which could cause the actual results, financial condition, performance or achievements of the Company to be materially different from those expressed or implied by such statements. Readers should therefore not place undue reliance on these statements, particularly not in connection with any contract or investment decision. The Company disclaims any obligation to update these forward-looking statements.

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Jasmine Petters

Jasmine Petters

Jasmine hails from the city of Nizams, Hyderabad, and is currently pursuing her M.D. from there only. She is an internet wizard and has keen passion in All Things tech. She is a regular Comment contributor for The Daily Telescope and writes a Web column, in which she covers war, sports, and everything in between.
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